E&M is a type of signaling using on analog telephone trunks.
E&M connections use an E and M wire in addition to the wires to carry the voice.
Since the voice can use either 2 wires or 4 wires, the total numbers of wires used on an E&M circuit is either 4 or 6.
The E wire was originally called the Ear lead and the M wire was originally called the Mouth lead.
Signals sent on these wire are typlically -48 volts, ground, and open.